Dairy Free | Vegan | Gluten Free | Vegetarian
Product information
ADVANCED ABSORPTION CURCUMIN
Integrative Therapeutics Curalieve provides advanced absorption curcumin due to its amorphous structure and excipient profile, which contributes to enhanced dispersibility and bioavailability. Curcumin has been studied and evaluated for its role in supporting antioxidant pathways and its effects on the body.*1,2 Curalieve’s key ingredient is curcuRouge®, an amorphous solid dispersion of curcumin.
HOW IT WORKSIn humans, curcumin is very poorly absorbed. Curalieve is formulated with curcuRouge®, an amorphous solid dispersion containing curcumin extract. Native curcumin has a propensity to form a crystalline structure that repels water. This crystalline structure is why consumption of native curcumin, even in gram amounts, yields little change in blood curcumin levels.3
The technology used to develop curcuRouge overcomes these challenges by first melting curcumin to reduce the crystalline structure, then rapidly dispersing the curcumin with food-based polymers. curcuRouge has a smaller particle size and improved dispersibility compared to native curcumin. The amorphous nature of curcuRouge contributes to its enhanced dispersibility, higher bioavailability as shown in both animal and human research.4
In a single-dose, double-blind, two-way crossover study, curcuRouge exhibited a higher bioavailability compared to submicron-particle colloidal dispersion.5
REFERENCES
- Li H, Sureda A, Devkota HP, et al. Biotechnol Adv. 2020;38:107343. doi:10.1016/j.biotechadv.2019.01.010
- Gautam SC, Gao X, Dulchavsky S. Adv Exp Med Biol. 2007;595:321-341. doi:10.1007/978-0-387-46401-5_14
- Lao, C. D., Ruffin, M. T., 4th, Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., & Brenner, D. E. (2006). BMC complementary and alternative medicine, 6, 10. https://doi.org/10.1186/1472-6882-6-10
- Wegiel, LA et al., Pharmaceutical Development and Technology, 2014; 18(8): 976-986. DOI: 10.3109/10837450.2013.846374
- Yoichi Sunagawa, Yusuke Miyazaki, et al. Journal of Functional Foods, Volume 81, 2021, 104443, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2021.104443\
ADVANCED ABSORPTION CURCUMIN
Integrative Therapeutics Curalieve provides advanced absorption curcumin due to its amorphous structure and excipient profile, which contributes to enhanced dispersibility and bioavailability. Curcumin has been studied and evaluated for its role in supporting antioxidant pathways and its effects on the body.*1,2 Curalieve’s key ingredient is curcuRouge®, an amorphous solid dispersion of curcumin.
HOW IT WORKSIn humans, curcumin is very poorly absorbed. Curalieve is formulated with curcuRouge®, an amorphous solid dispersion containing curcumin extract. Native curcumin has a propensity to form a crystalline structure that repels water. This crystalline structure is why consumption of native curcumin, even in gram amounts, yields little change in blood curcumin levels.3
The technology used to develop curcuRouge overcomes these challenges by first melting curcumin to reduce the crystalline structure, then rapidly dispersing the curcumin with food-based polymers. curcuRouge has a smaller particle size and improved dispersibility compared to native curcumin. The amorphous nature of curcuRouge contributes to its enhanced dispersibility, higher bioavailability as shown in both animal and human research.4
In a single-dose, double-blind, two-way crossover study, curcuRouge exhibited a higher bioavailability compared to submicron-particle colloidal dispersion.5
REFERENCES
- Li H, Sureda A, Devkota HP, et al. Biotechnol Adv. 2020;38:107343. doi:10.1016/j.biotechadv.2019.01.010
- Gautam SC, Gao X, Dulchavsky S. Adv Exp Med Biol. 2007;595:321-341. doi:10.1007/978-0-387-46401-5_14
- Lao, C. D., Ruffin, M. T., 4th, Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., & Brenner, D. E. (2006). BMC complementary and alternative medicine, 6, 10. https://doi.org/10.1186/1472-6882-6-10
- Wegiel, LA et al., Pharmaceutical Development and Technology, 2014; 18(8): 976-986. DOI: 10.3109/10837450.2013.846374
- Yoichi Sunagawa, Yusuke Miyazaki, et al. Journal of Functional Foods, Volume 81, 2021, 104443, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2021.104443\
INGREDIENTS
<1g
Total Carbohydrate
450mg
curcuRouge® enhanced bioavailable, amorphous curcumin extract from Curcuma longa rhizome
** Daily Value (DV) not established
†Percent daily value is based on a 2000 calorie diet
Other Ingredients
Curalieve Does Not Contain
Wheat
Gluten
Soy
Dairy
Artificial Flavors
Other Details
curcuRouge® is a registered trademark of Therabiopharma, Inc. and is used under license.
UPC: 871791110304
SKU: 13772
DIRECTIONS
Curalieve Directions and/or Dosage
Adults take 2 capsules daily. Do not exceed recommended dose.Warning
Do not take if you are pregnant or nursing. If you have gallstones, a bile duct obstruction, or if you are taking any medications, consult a healthcare professional before use. Keep out of reach of children. Safety sealed with inner seal. Do not use if seal is broken or missing. Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.INTERACTIONS
ADVANCED ABSORPTION CURCUMIN
Integrative Therapeutics Curalieve provides advanced absorption curcumin due to its amorphous structure and excipient profile, which contributes to enhanced dispersibility and bioavailability. Curcumin has been studied and evaluated for its role in supporting antioxidant pathways and its effects on the body.*1,2 Curalieve’s key ingredient is curcuRouge®, an amorphous solid dispersion of curcumin.
HOW IT WORKSIn humans, curcumin is very poorly absorbed. Curalieve is formulated with curcuRouge®, an amorphous solid dispersion containing curcumin extract. Native curcumin has a propensity to form a crystalline structure that repels water. This crystalline structure is why consumption of native curcumin, even in gram amounts, yields little change in blood curcumin levels.3
The technology used to develop curcuRouge overcomes these challenges by first melting curcumin to reduce the crystalline structure, then rapidly dispersing the curcumin with food-based polymers. curcuRouge has a smaller particle size and improved dispersibility compared to native curcumin. The amorphous nature of curcuRouge contributes to its enhanced dispersibility, higher bioavailability as shown in both animal and human research.4
In a single-dose, double-blind, two-way crossover study, curcuRouge exhibited a higher bioavailability compared to submicron-particle colloidal dispersion.5
REFERENCES
- Li H, Sureda A, Devkota HP, et al. Biotechnol Adv. 2020;38:107343. doi:10.1016/j.biotechadv.2019.01.010
- Gautam SC, Gao X, Dulchavsky S. Adv Exp Med Biol. 2007;595:321-341. doi:10.1007/978-0-387-46401-5_14
- Lao, C. D., Ruffin, M. T., 4th, Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., & Brenner, D. E. (2006). BMC complementary and alternative medicine, 6, 10. https://doi.org/10.1186/1472-6882-6-10
- Wegiel, LA et al., Pharmaceutical Development and Technology, 2014; 18(8): 976-986. DOI: 10.3109/10837450.2013.846374
- Yoichi Sunagawa, Yusuke Miyazaki, et al. Journal of Functional Foods, Volume 81, 2021, 104443, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2021.104443\
ADVANCED ABSORPTION CURCUMIN
Integrative Therapeutics Curalieve provides advanced absorption curcumin due to its amorphous structure and excipient profile, which contributes to enhanced dispersibility and bioavailability. Curcumin has been studied and evaluated for its role in supporting antioxidant pathways and its effects on the body.*1,2 Curalieve’s key ingredient is curcuRouge®, an amorphous solid dispersion of curcumin.
HOW IT WORKSIn humans, curcumin is very poorly absorbed. Curalieve is formulated with curcuRouge®, an amorphous solid dispersion containing curcumin extract. Native curcumin has a propensity to form a crystalline structure that repels water. This crystalline structure is why consumption of native curcumin, even in gram amounts, yields little change in blood curcumin levels.3
The technology used to develop curcuRouge overcomes these challenges by first melting curcumin to reduce the crystalline structure, then rapidly dispersing the curcumin with food-based polymers. curcuRouge has a smaller particle size and improved dispersibility compared to native curcumin. The amorphous nature of curcuRouge contributes to its enhanced dispersibility, higher bioavailability as shown in both animal and human research.4
In a single-dose, double-blind, two-way crossover study, curcuRouge exhibited a higher bioavailability compared to submicron-particle colloidal dispersion.5
REFERENCES
- Li H, Sureda A, Devkota HP, et al. Biotechnol Adv. 2020;38:107343. doi:10.1016/j.biotechadv.2019.01.010
- Gautam SC, Gao X, Dulchavsky S. Adv Exp Med Biol. 2007;595:321-341. doi:10.1007/978-0-387-46401-5_14
- Lao, C. D., Ruffin, M. T., 4th, Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., & Brenner, D. E. (2006). BMC complementary and alternative medicine, 6, 10. https://doi.org/10.1186/1472-6882-6-10
- Wegiel, LA et al., Pharmaceutical Development and Technology, 2014; 18(8): 976-986. DOI: 10.3109/10837450.2013.846374
- Yoichi Sunagawa, Yusuke Miyazaki, et al. Journal of Functional Foods, Volume 81, 2021, 104443, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2021.104443\
INGREDIENTS
<1g
Total Carbohydrate
450mg
curcuRouge® enhanced bioavailable, amorphous curcumin extract from Curcuma longa rhizome
** Daily Value (DV) not established
†Percent daily value is based on a 2000 calorie diet
Other Ingredients
Curalieve Does Not Contain
Wheat
Gluten
Soy
Dairy
Artificial Flavors
Other Details
curcuRouge® is a registered trademark of Therabiopharma, Inc. and is used under license.
UPC: 871791110304
SKU: 13772
DIRECTIONS
Curalieve Directions and/or Dosage
Adults take 2 capsules daily. Do not exceed recommended dose.Warning
Do not take if you are pregnant or nursing. If you have gallstones, a bile duct obstruction, or if you are taking any medications, consult a healthcare professional before use. Keep out of reach of children. Safety sealed with inner seal. Do not use if seal is broken or missing. Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.INTERACTIONS
Learn About Our Quality Standards