{"title":"Summer Savings","description":"\u003cp\u003e\u003cimg\u003e\u003cspan\u003eUp to 30% off. Discount shown in checkout\u003c\/span\u003e\u003cspan\u003e— From June 23-26 \u003c\/span\u003e\u003ca href=\"https:\/\/integrativepro.com\/pages\/legal-promotions\" title=\"Legal - Promotions\"\u003eTerms apply\u003c\/a\u003e\u003cspan\u003e*\u003c\/span\u003e\u003c\/p\u003e","products":[{"product_id":"active-b-complex","title":"Active B-Complex","description":"\u003cp\u003eB-VITAMINS PLAY ESSENTIAL ROLES IN MANY FUNCTIONS OF THE BODY\u003c\/p\u003e\u003cp\u003eOptimal folate and B vitamin intakes are associated with healthy neurological function as well as cardiovascular support.*\u003csup\u003e1,2\u003c\/sup\u003e Each B-vitamin exists in multiple forms, often referred to as vitamers. Active forms of vitamers are those that can be directly utilized by the body immediately. 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Vitamin B1 (as Thiamin) and Vitamin B2 (Riboflavin as riboflavin-5'-phosphate) serve as coenzymes essential for cell function, growth and energy production.*\u003csup\u003e1\u003c\/sup\u003e Vitamin B6 (as pyridoxal-5-phosphate and pyridoxine HCl) has an essential role in the synthesis of neurotransmitters, including serotonin, dopamine and gamma-aminobutyric acid (GABA).*\u003csup\u003e3 \u003c\/sup\u003eFolate has essential roles in nervous system and immune system function.*\u003csup\u003e1,4\u003c\/sup\u003e Vitamin B12 (as methylcobalamin) is essential for nervous system function, playing particular roles in myelin synthesis and nerve metabolism.*\u003csup\u003e5\u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003eREFERENCES\u003c\/p\u003e\u003csmall\u003e\u003col\u003e\n\u003cli\u003eKennedy DO et al. Nutrients. 2016;8(2):68.\u003c\/li\u003e\n\u003cli\u003eWald DS et al. BMJ. 2002;325(7374):1202. \u003c\/li\u003e\n\u003cli\u003eStover PJ et al. Adv Nutr. 2015;6(1):132-3. \u003c\/li\u003e\n\u003cli\u003eMaggini S et al. Nutrients. 2018;10(10):1531. \u003c\/li\u003e\n\u003cli\u003eCalderon-Ospina CA et al. CNS Neurosci Ther. 2020;26(1):5-13. \u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/small\u003e","brand":"ITI","offers":[{"title":"120 capsules","offer_id":50331888714042,"sku":"15065","price":35.0,"currency_code":"USD","in_stock":true},{"title":"60 capsules","offer_id":45323532173626,"sku":"10032","price":18.25,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0718\/9636\/7418\/files\/20260616_b8aa9712-e461-46f8-9363-e145256fc8c9.png?v=1781614774"},{"product_id":"berberine","title":"Berberine","description":"\u003cp\u003eWHAT IT DOES\u003c\/p\u003e\u003cp\u003eMETABOLIC SUPPORT*\u003c\/p\u003e\u003cp\u003eBerberine offers metabolic support for glucose and lipid metabolism.* It also supports healthy blood sugar and insulin levels already within a normal range.* Also supports healthy gastrointestinal function.* \u003c\/p\u003e\u003cp\u003eHOW IT WORKS\u003c\/p\u003e\u003cp\u003eClinical studies demonstrate that berberine supports healthy lipid metabolism and cholesterol homeostasis.*\u003csup\u003e1-6\u003c\/sup\u003e Berberine can activate an important metabolic enzyme known as adenosine monophosphate-activated protein kinase (AMPK), a central regulator of cellular energy homeostasis.* Mechanistic research in vitro and in vivo suggests that berberine can decrease cholesterol and triglyceride synthesis by activating AMPK.\u003csup\u003e7-9\u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003eIn addition to supporting lipid metabolism, berberine supports healthy glucose metabolism and blood sugar management already within a normal range.*\u003csup\u003e2-5\u003c\/sup\u003e Mechanistic research in vitro suggests that berberine can support healthy glucose regulation through promoting glucose uptake in cells via GLUT4 translocation.\u003csup\u003e7\u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003eREFERENCES\u003c\/p\u003e\u003csmall\u003e\u003col\u003e\n\u003cli\u003e Kong W et al. Nat Med. 2004;10(12):1344-51.\u003c\/li\u003e\n\u003cli\u003e Yin J et al. Metabolism. 2008;57(5):712-7.\u003c\/li\u003e\n\u003cli\u003e Zhang Y et al. J Clin Endocrinol Metab. 2008;93(7):2559-2565.\u003c\/li\u003e\n\u003cli\u003e Yang J et al. Evid Based Complement Alternat Med. 2012;2012:363845.\u003c\/li\u003e\n\u003cli\u003e Perez-Rubio K et al. Metab Syndr Relat Disord. 2013;11(5):366-9.\u003c\/li\u003e\n\u003cli\u003e  Cao C et al. Exp Ther Med. 2019;17(4):3009-3014.\u003c\/li\u003e\n\u003cli\u003e Lee YS et al. Diabetes. 2006;55:2256-64.\u003c\/li\u003e\n\u003cli\u003eBrusq JM et al. J Lipid Res. 2006;47(6):1281-8.\u003c\/li\u003e\n\u003cli\u003e Jiang D et al. Lipids Health Dis. 2016;15:214.\u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/small\u003e","brand":"ITI","offers":[{"title":"60 capsules","offer_id":45323532468538,"sku":"10711","price":32.75,"currency_code":"USD","in_stock":true},{"title":"120 capsules","offer_id":50318335279418,"sku":"15064","price":63.75,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0718\/9636\/7418\/files\/20260616_ce42f0a2-0f1f-4f5d-bc0e-d423d7d01beb.png?v=1781614775"},{"product_id":"cortisol-manager","title":"Cortisol Manager®","description":"\u003cp\u003eThe ingredients in Cortisol Manager support healthy cortisol levels.* Cortisol is one of the most important hormones involved in the adaptation process. By supporting balanced cortisol and a healthy stress response, Cortisol Manager also promotes relaxation to support restful sleep.*\u003c\/p\u003e\u003cp\u003eTHE ROLE OF CORTISOL IN TIMES OF STRESS\u003c\/p\u003e\u003cp\u003eCortisol is a hormone produced in the adrenal cortex that is released during times of stress. Variations in cortisol secretion can indicate how well the body is coping with stress. Cortisol homeostasis is typically characterized by peak secretion during the early morning hours with a gradual decline throughout the day. Because of its central role as a key stress hormone, cortisol is often thought of as a bridge between stress and its health impact.\u003c\/p\u003e\u003cp\u003eWITH HERBAL INGREDIENTS\u003c\/p\u003e\u003cp\u003eThe ingredients in Cortisol Manager help support a balanced, adaptive cortisol response to stress.* Cortisol Manager contains a stress-reducing proprietary blend of Sensoril® brand ashwagandha (\u003cem\u003eWithania somnifera\u003c\/em\u003e) and L-theanine.* A proprietary blend of Magnolia (\u003cem\u003eMagnolia officinalis\u003c\/em\u003e) and epimedium (\u003cem\u003eEpimedium koreanum\u003c\/em\u003e), as well as phosphatidylserine from soy lecithin are included in Cortisol Manager.\u003c\/p\u003e\u003cp\u003eA 2008 placebo-controlled clinical trial showed that Sensoril® ashwagandha significantly reduced serum cortisol levels and helped manage stress compared to placebo, in subjects experiencing higher levels of stress.*\u003csup\u003e1\u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003eThe ingredients in Cortisol Manager help support relaxation to promote restful sleep.* They also help stabilize the stress hormone cortisol to further support a healthy stress response.*\u003c\/p\u003e\u003cp\u003eREFERENCES\u003c\/p\u003e\u003csmall\u003e\u003col\u003e\n\u003cli\u003eAuddy B et al. 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By supporting balanced cortisol and a healthy stress response, Cortisol Manager Allergen Free also promotes relaxation to support restful sleep.*\u003c\/p\u003e\u003cp\u003eCortisol Manager Allergen Free does not contain any of the top 9 most common food allergens and is ideal for patients with food sensitivities or food allergies.\u003c\/p\u003e\u003cp\u003eTHE ROLE OF CORTISOL IN TIMES OF STRESS\u003c\/p\u003e\u003cp\u003eCortisol is a hormone produced in the adrenal cortex that is released during times of stress. Variations in cortisol secretion can indicate how well the body is coping with stress. Cortisol homeostasis is typically characterized by peak secretion during the early morning hours with a gradual decline throughout the day. Because of its central role as a key stress hormone, cortisol is often thought of as a bridge between stress and its health impact.\u003c\/p\u003e\u003cp\u003eWITH HERBAL INGREDIENTS\u003c\/p\u003e\u003cp\u003eThe ingredients in Cortisol Manager Allergen Free help support a balanced, adaptive cortisol response to stress.* Cortisol Manager contains a stress-reducing proprietary blend of Sensoril® brand ashwagandha (\u003cem\u003eWithania somnifera\u003c\/em\u003e) and L-theanine.* \u003c\/p\u003e\u003cp\u003eA 2008 placebo-controlled clinical trial showed that Sensoril® ashwagandha significantly reduced serum cortisol levels and helped manage stress compared to placebo, in subjects experiencing higher levels of stress.*\u003csup\u003e1\u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003eThe ingredients in Cortisol Manager Allergen Free help support relaxation, to promote restful sleep.* They also help stabilize the stress hormone cortisol to further support a healthy stress response.*\u003c\/p\u003e\u003cp\u003eCortisol Manager Allergen Free does not contain any of these common food allergens: milk, eggs, tree nuts, fish, shellfish, sesame, peanuts, soy, or wheat.  ‡ Manufacturer verified: Does not contain any of the top 9 most common food allergens.\u003c\/p\u003e\u003cp\u003eREFERENCES\u003c\/p\u003e\u003csmall\u003e\u003col\u003e\n\u003cli\u003e Auddy B et al. J Am Nutraceutical Assoc. 2008;11(1):50-6.\u003c\/li\u003e\n\u003cli\u003e Nobre AC et al. 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Human clinical trials show that Theracurmin® is over 27 times more bioavailable than a standard curcumin extract and is many times more bioavailable than other commercially-available curcumin supplements.1,2 Theracurmin® curcumin extract has been clinically shown to support detoxification pathways, healthy cardiovascular function, muscle recovery after acute exercise and provide relief of minor pain due to occasional overuse.*\u003csup\u003e1,3-5\u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003eBIOLOGICAL EFFECTS OF CURCUMIN\u003c\/p\u003e\u003cp\u003eIn vitro and in vivo research demonstrates that curcumin supports detoxification and cytokine pathways.*\u003csup\u003e6,7\u003c\/sup\u003e While mechanisms of action are still under investigation, the chemical structure of curcumin directly influences antioxidant pathways, with its phenolic hydroxyl group behaving as an electron donor.\u003csup\u003e7\u003c\/sup\u003e Based on in vitro and in vivo studies, curcumin's indirect effects on antioxidant pathways include modulating cellular redox homeostasis and enhancing the activity of antioxidant enzymes like catalase, superoxide dismutase, glutathione peroxidase and glutathione-S-transferase, enzymes that also support detoxification and cytokine pathways.\u003csup\u003e7\u003c\/sup\u003e\u003c\/p\u003e\u003cp\u003eREFERENCES\u003c\/p\u003e\u003csmall\u003e\u003col\u003e\n\u003cli\u003eSasaki H et al. Biol Pharm Bull. 2011;34(5):660-5.\u003c\/li\u003e\n\u003cli\u003e Sunagawa Y et al. J Nutr Sci Vitaminol. 2015;61:37-44.\u003c\/li\u003e\n\u003cli\u003eAkazawa N et al. Nutr Res. 2012;32(10):797-9.\u003c\/li\u003e\n\u003cli\u003eTanabe Y et al. Eur J Appl Physiol. 2015;115(9):1949-57.\u003c\/li\u003e\n\u003cli\u003eNakagawa Y et al. J Orthop Sci. 2014;19:933-9. \u003c\/li\u003e\n\u003cli\u003eGupta SC et al. Clin Exp Pharmacol Physiol. 2012;39(3):283-99.\u003c\/li\u003e\n\u003cli\u003eXu XY et al. 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